This research report provides framework and recommendations for guidelines for designing and maintaining New Jersey bridges to resist multiple hazards, based om literature reviews, input of subject matter experts (SMEs), and researchers’ findings and studies. It identifies various hazards such as earthquakes, flooding, storm surge, scour, wind, collisions, fire, blast, and site-specific risks for structural system guidance covering superstructures, substructures, connections, and energy dissipation measures. Individual hazards in accordance with AASHTO, NJDOT, and NJDEP requirements was described to explain how to address multi-hazard interactions through appropriate load combinations. Implementation guidelines are proposed for integration with NJDOT design procedures.